protective effect of ricinus communis leaves extract on carbon tetrachloride induced hepatotoxicity in albino rats

Authors
abstract

ricinus communis linn. (euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. in the indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a long time. in the present study, the protective effects of ethanol extract of ricinus communis l. leaves on carbon tetrachloride-induced liver damage were investigated in rats. results were compared with those of silymarin, a standard hepatoprotective drug. it was found that an increase in the activities of serum transaminases and the level of liver lipid peroxidation, protein, glycogen and the activities of acid and alkaline phosphatase in liver induced by ccl4 were significantly inhibited by treatment with ricinus communis ethanolic extract (250/500mg/kg b.wt). in addition, the depletion of glutathione level and adenosine triphosphatase activity observed in the ccl4-induced rat liver were effectively prevented by treatment with ricinus communis ethanolic extract (250/500mg/kg b.wt). histopathological examination further confirmed the hepatoprotective activity of ricinus communis ethanol extract when compared with the ccl4-induced control rats. in conclusion, these results indicate that the ethanol extract of ricinus communis ethanolic extract exhibits hepatoprotective action.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Protective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

       Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...

full text

Protective Effect of Berberis integerrima Fruit Extract on Carbon-Tetrachloride Induced Hepatotoxicity in Rats

Background & Objective: Hepatoprotective effect of antioxidants such as flavnoids has been demonstrated. The aim of the present study was to assess the hepatoprotective effect of the methanolic extract of Berberis integerrima fruit (MEBIF) on carbon-tetrachloride (CCL4) induced hepatotoxicity in rats. Materials & Methods: Forty male rats were divided into 5 groups as follows: 1) normal, 2) toxi...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effect of Aqueous Leaves Extract of Gardenia ternifolia Plant on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

The effects of aqueous leaves extract of the Gardenia ternifolia plant (ALEGTP) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Thirty albino rats were used for the experiment and grouped into six (n=5); group 1 and 2 were normal and control respectively. Group 3 was pretreated with silymarin while group 4, 5 and 6 were pretreated with 100, 200 and 400 mg/kg...

full text

Effect of Ginkgo biloba Leaves Aqueous Extract on Carbon Tetrachloride Induced Acute hepatotoxicity in rats

Bachground: Oxidative stress plays a pivotal role in the pathogenesis and progression of various liver diseases. Ginkgo biloba leaves extract (GbE) have been proved to be an effective antioxidant, thereby can contribute to the prevention and treatment of diseases associated with oxidative stress. The present study aimed to investigate the hepatoprotective effect of GbE on acute liver injury ind...

full text

Protective Effect of N-Acetyl Cysteine in Carbon Tetrachloride-Induced Hepatotoxicity in Rats

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical sciences

جلد ۷، شماره ۴، صفحات ۲۶۹-۲۷۸

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023